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-synuclein, that's a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) tension, advise that dysfunction with the intracellular proteinase techniques, which include ubiquitin-proteasome program or lysosomal procedure, which eliminates avoidable t